blood type b and covid vaccine side effects

To date, most of the Chinese population has been vaccinated with the inactivated vaccine. This can be a sign of anaphylaxis, a severe allergic reaction. The early response observed 30 days after the second dose showed a boost effect linked to the same manufacturers scheme. 2022 Feb;29(2):555-563. doi: 10.1111/ene.15147. Science-based COVID-19 vaccine development. Yin F, Wu Z, Xia X, Ji M, Wang Y, Hu Z. The results were notable: Adjusting for demographics and co-morbidities, the risk for a COVID-19 diagnosis was 12 percent lower for people with type O blood and the risk for severe COVID-19 or death was 13 percent lower, compared to those with A, AB, or B blood types. 8 A total of 3 643 918 persons were enrolled in v-safe and completed at least 1 health survey within 7 days following their first vaccine dose; 1 920 872 v-safe participants reported receiving a second vaccine dose and completed at . All authors contributed to the article and approved the submitted version. Tianjin CanSino produces the adenovirus vaccine type for a vaccination program of one dose and Anhui Zhifei produces the recombinant protein vaccine type for a vaccination program of three doses at intervals of 1 month (12). Blood type, the researchers found, stood out as a potential key difference between the two groups. Lancet Infect Dis (2022) 22:47382. Front. doi:10.1056/NEJMoa2027187, Keywords: cellular immune response, COVID-19, inactive vaccine, kinetics, neutralizing antibody, Citation: Yuan Y, Xu J, Ma B, Chen G, Wang Z, Wang S, Jing N, Zhang J, Wang B, Yan W, Zhang Q, Zhao Q and Li Y (2023) Characteristics of humoral and cellular responses to coronavirus disease 2019 (COVID-19) inactivated vaccine in central China: A prospective, multicenter, longitudinal study. Just because youre Type O doesnt mean youre in the clear. Healthcare professionals, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should stay vigilant to recognize them early and treat them adequately. Even DNA testing company 23andMe tapped their customers and found that among 750,000 people who were diagnosed and hospitalized for Covid (this was prior to vaccines), those with type O were more protected. Not everyone gets side effects. Pain at the injection site, alongside redness and/or swelling Extended fatigue Headaches Widespread muscle pain Joint pain Chills Fever Nausea and vomiting According to current FDA publications,. Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). Molly Walker, Associate Editor, MedPage Today Among them, Beijing Kexing Zhongwei, Beijing Kexing, Beijing Biology, Lanzhou Biology, Wuhan Biology, and Changchun Biology produce the inactivated vaccine type for a vaccination program of two doses at an interval of 38 weeks. Progress and challenge of COVID-19 vaccine development. This narrative review was conducted to collect and discuss published data about neurological side effects of SARS-CoV-2 vaccines in order to discover type, frequency, treatment, and outcome of these side effects. The retailer is being called out over its strict security measures. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. This weird trivia you didn't know about the world will blow you away. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. Among 11,000 patients, blood type A was not associated with increased viral positivity (OR 0.97, 95% CI 0.93-1.01, P=0.11), hospitalization (OR 0.89, 95% CI 0.80-0.99, P=0.03) or ICU admission (OR 0.84, 95% CI 0.69-1.02, P=0.08) compared to type O, and neither were there associations with worse outcomes among patients type B or AB, reported Jeffrey Anderson, MD, of the University of Utah School of Medicine in Salt Lake City, and colleagues. Latest research and advice on side effects and allergic reactions related to COVID-19 vaccines. Anderson's group examined data from Intermountain Healthcare, an integrated system of 24 hospitals and 215 clinics in Utah, Idaho, and Nevada. Moderna says 9.7% of their participants felt fatigued and 4.5% got . CNN . The retailer's cutting-edge new offering is angering some local residents. While Anderson and colleagues noted their sample was mostly white, with a minority contribution from other ethnicities, they added their results were similar when restricted to white race alone. Lower antibody concentrations were correlated with older age, longer duration after vaccination, non-health care workers, mixed-manufacturer vaccinations, and intervals of less than 40 days between two doses of vaccination, whereas lower IFN- levels and B-lymphocyte counts were associated with older age, blood type A, and non-health care workers. "Rh blood type was protective against SARS-CoV-2 infection, especially for those who were O-negative," they wrote. A review of neurological side effects of COVID-19 vaccination. Data are presented as mean (95% confidence interval [CI]) from the linear mixed-effects model adjusted for vaccine manufacturer, sex, blood type, age, occupation, and BMI. In both intervention and control groups, the positive rate of neutralizing IgG antibodies specific to the SARS-CoV-2 RBD slowly increased to 84.1% from 1 to 14 days, peaked at 97.7% from 60 to 90 days, and then slowly decreased and remained at 82.9% from 180 to 240 days after the second vaccination. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, 1. This site needs JavaScript to work properly. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Blood clots with low platelets Capillary leak syndrome Guillain-Barr syndrome (GBS) Ongoing monitoring of side effects and reactions As the COVID-19 vaccine rollout continues across Canada, safety monitoring is ongoing. Keywords: Based on their data, the Novavax vaccine has a significantly lower rate of side effects compared to the Pfizer-BioNTech and Moderna vaccines. Interested candidates contacted one of the study institutions directly; at this point, a personal interview was scheduled to explain the study and verify the selection criteria. In conclusion, this study is the first to evaluate robust humoral and cellular immune responses at 240 days in 595 participants after a second dose of inactivated vaccine in individuals primed with the first dose. Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. We know the Covid virus damages the lining of your blood vessels. Associations were observed between blood type and production of neutralizing antibodies and IFN-. Because each set underwent nine comparisons, significance for individual comparisons was set at P=0.006, meaning none of these associations were significant, they wrote in JAMA Network Open. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. In China, the latter three have been approved and are produced by eight manufacturers. Cell Res (2022) 32:1036. The American Red Cross reports that 8 percent of white Americans, 4 percent of African-Americans, 4 percent of Latinx-Americans, and 1 percent of Asian-Americans are O-negative. Microbiol Spectr (2022) 10:e0118121. But VWF also encourages clotting. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. What You Need to Know The positive rate of neutralizing antibodies peaked at 97.7% at 6090 days, decreased, and stabilized at 82.9% at 181240 days post-vaccination. doi:10.1016/j.jclinepi.2021.12.015, 4. One study published by the CDC reports that from March 2020 to January 2021, patients with COVID-19 had nearly 16 times the risk for myocarditis compared with patients who did not have COVID-19. 04:20. Hearst Magazine Media, Inc. All Rights Reserved. Women and younger adults tend to have more side effects than men or older adults do. doi:10.3760/cma.j.cn112147-20200928-01013, 5. Costa Clemens SA, Weckx L, Clemens R, Almeida Mendes AV, Ramos Souza A, Silveira MBV, et al. That is the most troubling unknown for me." Weighing the odds The virus can lead to pneumonia, respiratory failure, heart problems, liver problems, septic shock, and death. Zhonghua Jie He He Hu Xi Za Zhi (2021) 44:49296. They looked at patients from March 3 to Nov. 2, 2020 who were tested for SARS-CoV-2 and had a recorded blood type, comparing positive versus negative tests, hospitalized versus non-hospitalized patients and ICU versus non-ICU patients. Side effects may even feel like flu and might affect your ability to do daily activities,. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Antigen-specific humoral immune responses were detected using a commercial enzyme-linked immunosorbent assay (ELISA) anti-SARS-CoV-2 S kit (Shanghai GeneoDx Biotech, Ltd., Co., Shanghai, China), which detects neutralizing immunoglobulin G (IgG) antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD) on a universal microplate reader (DNM-9602; Beijing Pulang Ltd., Co., Beijing, China); values > 6.5 IU/mL were considered positive. Congestion/runny nose. Since both of those types are fairly rare, the Red Cross works hard to . } ); HHS Vulnerability Disclosure, Help Most side effects are mild and normally last only a day or two. Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: A randomised, open-label, single-centre trial. Gao GF. Front Neurol. Nat Commun (2020) 11:5761. doi:10.1038/s41467-020-19623-x, 20. Vaccine (2022) 40:218490. The levels of cellular immune molecules, such as IFN- and CD4+ T-lymphocytes, reflect the levels of effector molecules involved in the humoral immune response, such as memory B cells and neutralizing antibodies (26). These antibodies can also bind to and activate platelets, priming them to clump together and trigger clotting. Hum Vaccin Immunother (2022) 18:2078634. doi:10.1080/21645515.2022.2078634, 9. To control the COVID-19 epidemic and build an active immunization barrier among populations, the Chinese Government provided free COVID-19 vaccination to all citizens as of December 2020 (3). This may explain why individuals with blood type A were more susceptible to SARS-CoV-2 infection than those with other blood types. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). SARSCoV2 vaccines are not free of neurological side effects. We may earn commission from links on this page, but we only recommend products we back. No use, distribution or reproduction is permitted which does not comply with these terms. Table6 Factors associated with IL-6 level after the administration of the Chinese COVID-19 inactivated vaccine. Post SARSCoV2 vaccination GuillainBarre syndrome in 19 patients. Many COVID-19 . doi:10.1080/14760584.2021.1971523, 13. Source Reference: Anderson JL, et al "Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population" JAMA Netw Open 2021; DOI: 10.1001/jamanetworkopen.2021.7429. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. Natl Sci Rev (2021) 8:nwab193. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: A preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. People with blood type O may be less vulnerable to Covid-19 and have a reduced likelihood of getting severely ill, according to two studies published Wednesday. The https:// ensures that you are connecting to the Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. It also can be potentially quite large and thus a bit unsettling. O is the most common blood type in the U.S.: 37 percent of white Americans fall into this category, according to the American Red Cross, with the numbers rising to 47 percent among African-Americans, 53 percent among Latinx-Americans, and 39 percent of Asian-Americans. doi:10.1016/j.vaccine.2022.02.065, 16. In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. Unfortunately, this is a much more rare blood type. Immune cellular responses at 1240 days after the second dose of vaccine also supported the same manufacturers approach. However, in this study, the GMC in participants in the mixed-manufacturer group was lower than that in participants in the same-manufacturer group, which is perhaps due to the fact that vaccines from different manufacturers were still of the same type (both inactivated vaccines, but a protein or attenuated live vaccine). No. It's more the everyday things: According to Harvard Medical School physician Abraar Karan, the primary side effects of the COVID-19 vaccine are those pesky, flu-like, symptoms you're used. Feelings of having a fast-beating, fluttering or pounding heartbeat COVID can cause heart problems, too Having COVID-19 can also cause heart problems. A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. Boosting vaccination is considered important, as antibodies and cellular immune responses were reduced in susceptible populations. Vaccines are still important, as are smart choices to protect yourself from germs. Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. To analyze the changes in neutralizing antibodies and cellular immune responses over time, we used a mixed linear model with continuous natural log10-transformed cellular immune response data or the log2-transformed concentration of neutralizing antibodies against SARS-CoV-2 spike protein between days 1 and 240 as the dependent variable; age, sex, body mass index (BMI), occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood were included as covariates in the models. The original contributions presented in the study are included in the article/Supplementary Material. Whether the immunogenic response observed in this study will translate to better efficacy and effectivenessa fact that should be considered in strategic decisions about vaccination programsis unknown. "It's pretty clear that Type O is protective to some degree. Also, if possible, get some rest. Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. But VWF also . When a vaccine is injected, the body's immune response jumps into action, responding to the presence of a foreign entity. Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, et al. Those four main blood groupsA, AB, B, and Ocan be Rh-positive or Rh-negative, meaning that there are 8 blood groups in total. Opens in a new tab or window, Visit us on YouTube. J Med Virol (2022) 94:411524. Desmecht S, Tashkeev A, El MM, Marechal N, Pere H, Tokunaga Y, et al. Borobia AM, Carcas AJ, Prez-Olmeda M, Castao L, Bertran MJ, Garca-Prez J, et al. Four types of COVID-19 vaccine have been approved for use worldwide: mRNA, inactivated virus, adenovirus, and recombinant protein vaccines (11). In this study, the older population produced lower levels of neutralizing antibodies, IFN-, B-lymphocytes, and IL-6, similar to that in previous studies (3, 25). The Centers for Disease Control and Prevention on Friday published new data listing the most common side effects Americans reported after receiving shots of Pfizer 's or Moderna 's Covid-19 vaccines. Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. Patients were identified based on self-report of receiving the vaccine. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). Interestingly, the concentration of neutralizing antibodies decreased by an average of 0.004 IU (95% confidence interval [CI]: 0.0020.005, p < 0.001) per day after vaccination (Table2). The platelets, which normally promote wound healing, end up clumping and causing blood. (EG) Kinetics of interferon (IL)-6 levels according to (E) age, (F) vaccine manufacturer, (G) occupation and (H) interval between doses of vaccination. Blood type is not associated with a severe worsening of symptoms in people who have tested positive for COVID-19, report Harvard Medical School researchers based at Massachusetts General Hospital. 30. On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group . Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). This finding suggests that cellular immune responses lasted longer than humoral responses in the vaccinated population. Previous research has found that people with A blood types are more at risk. Bethesda, MD 20894, Web Policies There was no association with blood type and either susceptibility to COVID-19 infection or disease severity in a large cohort study, researchers said. B negative patients can only receive blood from other B negative donors or from type O negative donors (who are the universal donors). Reactogenicity analysis was based on solicited adverse events in 425 and 143 participants from the control and intervention groups, respectively, 30 days after vaccination. Follow. Experts say more . We identified age as a contributing factor; with increasing age, the antibody concentration generated was decreased, and the rate of decrease in the neutralizing antibody concentration was rapid (age 3150 years vs. age 1830 years, B = 0.31, 95% CI 0.5 to 0.1; p = 0.009; Table2; Figure2C). J Clin Epidemiol (2022) 144:16372. If You Have One of These Blood Types, You May Be Safe From COVID, It Only Takes This Long to Get COVID in a Room With Someone Who Has It, These 2 Places Could Be Closing Soon, White House Official Warns, How Likely You Are to Catch COVID in the Next Month, Expert Says, If You Have This Symptom, There's an 80 Percent Chance You Have COVID, tracked the blood types of nearly 2,200 COVID-19 patients, A blood types were significantly more likely. Editorial: Rebound COVID-19 and cessation of antiviral treatment for SARS-CoV-2 with paxlovid and molnupiravir. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. Socio-economic status is a big vulnerability, and age and health are next in line for susceptibility. doi:10.1016/S1473-3099(21)00680-0, 27. Lancet Infect Dis (2022) 22:5663. Association between mRNA vaccination and COVID-19 hospitalization and disease severity. Research is still finding clues about who's more susceptible and why. These include anaphylaxis, a severe reaction . U.S. federal health agencies have recommended pausing the use of Johnson & Johnson's COVID-19 vaccine after six recipients developed a rare disorder involving blood clots, in a fresh setback to . Li G, Cappuccini F, Marchevsky NG, Aley PK, Aley R, Anslow R, et al. If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. Common side effects include fatigue and headache. (D) Kinetics of B-lymphocyte count according to age. Would you like email updates of new search results? B negative red blood cells can be given to both B and AB patients. "Or by being Type O, the virus gets in but the A antibody prevents it from docking with enough cells to cause disease. NJ, BW, QiZ, and JZ analyzed the immune data of the participants. We dont know why people with Type O might possibly be more protectedbut there are a lot of theories. Side effects can be a powerful deterrent stopping people from getting vaccinated. Saur D, ORyan M, Torres JP, Zuniga M, Santelices E, Basso LJ. In the future, we will include more participants after administering booster vaccines and conduct pseudo-virus neutralization tests to address these limitations. To address this issue, in 1991, a group of scientists in Minnesotaat the Department of Veterans Affairs and the . The most frequent of them are headache, GBS, VST, and transverse myelitis. A total of 1,350 serum samples were collected from 595 participants (Figure1), of whom 457 (76.8%) were medical staff and 138 (23.2%) were workers of the Henan Electric Power Exploration Company in central China. Bookshelf The concentration kinetics of IgG neutralizing antibodies were evaluated against the RBD for all study participants at least once during the 8-month timeframe and at least four times for 119 participants (20%). Si vous ne souhaitez pas que nos partenaires et nousmmes utilisions des cookies et vos donnes personnelles pour ces motifs supplmentaires, cliquez sur Refuser tout. Immune responses to the heterologous vaccination schedule were within the range of those reported using homologous schedules. Careers. There's no known connection between blood types and side effects from COVID-19 vaccines. Similarly, previous studies reported that patients with blood group A had an increased risk of infection with SARS-CoV-2, whereas those with blood group O were associated with a decreased risk (21, 24). 2022 Dec 6;10(34):12617-12622. doi: 10.12998/wjcc.v10.i34.12617. This can result in pain, redness, or swelling at . People with Type O blood might be slightly more protected from the virus, and people with Type A slightly more vulnerable. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. All participants provided their informed consent in writing before enrollment. From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. Opens in a new tab or window, Visit us on Instagram. The results showed that those with A blood types were significantly more likely to contract the coronavirus compared with other blood types. } Second, the reported adverse events could also have been underestimated due to the small number of participants and short observation period. Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: A sentinel surveillance study. Exacerbating GuillainBarr syndrome eight days after vectorbased COVID19 vaccination. Applies to sars-cov-2 (covid-19) mrna-1273 vaccine: intramuscular suspension. An independent data-monitoring committee, comprising independent scientists not involved in this study, has been reviewing the data regularly for safety and scientific integrity. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. In addition, people who are Black, who have died at a disproportionately high rate from Covid, tend to have higher levels of VWF, too. 2023;47(1):5. doi: 10.1186/s42269-023-00981-7. These include: chills fatigue fever headache muscle pain nausea pain at the injection site redness at the. National Library of Medicine 2021;76:e3286. Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. Kaulen LD, Doubrovinskaia S, Mooshage C, Jordan B, Purrucker J, Haubner C, Seliger C, Lorenz HM, Nagel S, Wildemann B, Bendszus M, Wick W, Schnenberger S. Eur J Neurol. This study was a multicenter, longitudinal, prospective, observational study conducted in two hospitals (Henan Provincial Peoples Hospital and Zhengzhou Municipal Chinese Medicine Hospital) and one institution (Henan Electric Power Survey and Design Institute) in central China. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. Accessibility In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. 2021 John Wiley & Sons A/S. Vaccination is the most effective measure to reduce mortality from COVID-19 and serious diseases (12); however, vaccines are scarce in certain countries and some regions in China (13). This "Covid arm" rash can be red, itchy, swollen, or painful. The clots can clog up important . The participants in the study (mixed-manufacturer vaccination for the two doses) and control (same-manufacturer vaccination for both doses) groups remained in local community health centers for at least 30min after vaccination to monitor safety, and the occurrence of any adverse event during this observation period was recorded.

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